AUGUST 2023

SARS-CoV-2 / COVID-19

• Sanford Guide SARS-CoV-2 / COVID-19 main page.
• COVID-19 vaccination in cancer patients: recommendations from NCCN here.
• Currently authorized vaccines. See COVID-19 Prevention for table summarizing use and data.
• ESCMID COVID-19 living guidelines: drug treatment and clinical management (Clin Microbiol Infect 2022;28:222). Available at PMC.
• Guidelines on COVID-19 diagnosis, serology, treatment and management, and infection prevention: IDSA and NIH.
• Living WHO guideline on drugs for COVID-19 (BMJ 2021;375:n2936).
• Living WHO guideline on drugs to prevent COVID-19 (BMJ 2021;372:n526). Available here.
• Living WHO guideline on prophylaxis against COVID-19 (BMJ 2021;373:n949). Available at PMC.
• Management of hospitalized adults with COVID-19: a European Respiratory Society living guideline (Eur Respir J 2021;57(4):2100048). Available at PMC.

Drug Shortages (US)

• Bicillin-LA and Bicillin-CR availability: See Dear Healthcare Professional letter here.
• Antimicrobial drugs or vaccines in reduced supply or unavailable (as of August 6, 2023) due to increased demand, manufacturing delays, product discontinuation by a specific manufacturer, or unspecified reasons: 
  • New shortages since July 10, 2023:
    
    • Tedizolid injection
      
  • Shortage recently resolved:
    • Azithromycin injection
    • Clotrimazole 10 mg oral troches
      
    • Rifampin injection
    • Rifapentine 150 mg tablets
    • Rifaximin tablets (200 mg, 550 mg)
  • Antibacterial drugs:
    • Aminoglycosides:
      • Amikacin injection
      • Gentamicin injection
      • Neomycin tablets
      • Tobramycin injection
    • Bacitracin ophthalmic ointment (unavailable)
    • Carbapenems:
      • Meropenem injection
    • Cephalosporins:
      • Cefazolin injection
      • Cefdinir (all oral formulations)
      • Cefixime 400 mg capsules
      • Cefotaxime injection (FDA is allowing temporary importation of product from SteriMax in Canada, in conjunction with Provepharm Life Solutions and its distributor Direct Success. Click here for details),
    • Clindamycin injection
    • Doxycycline oral suspension
    • Fluoroquinolones:
      • Ciprofloxacin injection
      • Ciprofloxacin 0.3% ophthalmic solution
      • Ofloxacin 0.3% ophthalmic solution
    • Glycopeptides, glycolipopeptides, lipopeptides:
      
      • Vancomycin injection
    • Macrolides/azalides:
      
      • Azithromycin ophthalmic solution 1% (unavailable)
      • Erythromycin 0.5% ophthalmic ointment
    • Metronidazole injection
    • Neomycin and Polymyxin B Sulfates GU Irrigant
    • Nitrofurantoin oral suspension
    • Penicillins:
      • Amoxicillin (all oral formulations)
      • Amoxicillin-clavulanate (all oral formulations)
      • Dicloxacillin capsules (250 mg, 500 mg)
      • Penicillin G benzathine injection (Bicillin-LA)
      • Penicillin G benzathine/Penicillin G procaine (Bicillin-CR)
      • Penicillin VK tablets (250 mg, 500 mg), oral solution (250 mg/5 mL)
      • Piperacillin-tazobactam injection
    • Polymyxin B sulfate/Trimethoprim sulfate ophthalmic solution
    • Sulfacetamide 10%/Prednisolone 0.2% ophthalmic ointment (unavailable)
    • Sulfanilamide 15% vaginal cream (unavailable)
    • Tedizolid 200 mg tablets
  • Antifungal drugs: 
    
    • Amphotericin B injection
    • Amphotericin B Lipid Complex (ABLC)
  • Antimycobacterial drugs: 
    
    • Isoniazid injection (100 mg/mL)
    • Isoniazid 100 mg, 300 mg tablets
    • Rifampin capsules
  • Antiparasitic drugs:
    • Primaquine
  • Antiviral drugs: 
    
    • Oseltamivir capsules, powder for oral suspension
    • Podofilox 0.5% topical gel
    • Ribavirin for inhalation solution
    • Valganciclovir tablets, powder for oral solution
  • Vaccines:
    • None
      

• Antimicrobial drugs recently discontinued: 
  • Penicillin G procaine 600,000 units/mL IM injection (June 2023)
  • Ritonavir oral solution 80 mg/mL (January 2023)
  • Lindane 1% shampoo (discontinued by Wockhardt USA in June 2022, no other supplier)
  • Quinupristin-Dalfopristin (discontinued by Pfizer in early 2022, no other supplier)
  • Gemifloxacin 320 mg tablet (August 2022, no further US distribution)
  • Gentamicin sulfate 0.3% ophthalmic ointment (July 2022)
  • Mupirocin calcium 2% cream (Bactroban [GSK], June 2020)
  • Bacitracin injection (February 2020)
  • Interferon alfa-2b (Intron A, October 2019)
  • Mupirocin calcium 2% nasal ointment (Bactroban Nasal [GSK], August 2019)

• For more detailed information including estimated resupply dates, see https://www.ashp.org/Drug-Shortages/