AUGUST 2024

From IDSA

• 2024 Guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intraabdominal infections in adults, children, and pregnant people. This is part 1 of an update to the 2010 SIS/IDSA guidelines. Click here.
• 2024 Guidance update focused on antimicrobial-resistant infections caused by extended-spectrum β-lactamase-producing Enterobacterales, AmpC β-lactamase-producing Enterobacterales, carbapenem-resistant Enterobacterales, Pseudomonas aeruginosa with difficult-to-treat resistance, carbapenem-resistant Acinetobacter baumannii, and Stenotrophomonas maltophilia. This update replaces earlier versions. Click here.

Antimicrobial Shortages (US)

• New shortages:
  • Fluconazole injection (9 Aug 2024)
    
• Shortages recently resolved:
  • Erythromycin 0.5% ophthalmic ointment (26 Jul 2024)
  • Amphotericin B injection (6 July 2024)
    
• Antimicrobial drugs or vaccines in continued reduced supply or unavailable (as of 11 August 2024) due to increased demand, manufacturing delays, product discontinuation by a specific manufacturer, or unspecified reasons: 

  • Antibacterial drugs:
    • Aminoglycosides:
      
      • Gentamicin injection (22 Feb 2021)
    • Cephalosporins:
      • Cefazolin injection (4 Jun 2018)
      • Cefdinir 300 mg capsules (29 Jun 2023)
      • Cefdinir 125 mg/5 mL, 250 mg/5 mL oral suspension (29 Jun 2023)
      • Cefotaxime injection (10 Jun 2015)
        
        • FDA is allowing temporary importation of product from SteriMax in Canada, in conjunction with Provepharm Life Solutions and its distributor Direct Success. Click here for details.
    • Chloramphenicol injection (9 Oct 2023)
    • Clindamycin phosphate injection (25 Jun 2015)
    • Fluoroquinolones:
      • Ciprofloxacin injection (13 Jan 2023)
      • Levofloxacin injection in D5W (29 May 2024)
      • Levofloxacin oral solution, 25 mg/mL (15 Sep 2023)
      • Moxifloxacin 400 mg tablets (6 Dec 2023)
      • Ofloxacin 0.3% ophthalmic solution (22 Dec 2022)
    • Glycopeptides, glycolipopeptides, lipopeptides:
      
      • Vancomycin injection (1 Jun 2015)
    • Metronidazole injection (20 Oct 2021)
    • Neomycin and Polymyxin B Sulfates GU Irrigant (25 Jun 2023)
    • Nitrofurantoin oral suspension (5 Jun 2018)
    • Penicillins:
      • Amoxicillin, all oral formulations (18 Oct 2022)
      • Amoxicillin-clavulanate, all oral formulations (17 Nov 2022)
      • Ampicillin injection (19 Oct 2023)
      • Dicloxacillin 250 mg, 500 mg capsules (18 Aug 2021)
      • Nafcillin injection (20 Mar 2024)
      • Penicillin G benzathine injection (1 Feb 2023) Availability update here
      • Penicillin G benzathine/Penicillin G procaine (31 Mar 2023) Availability update here
      • Penicillin VK oral solution 250 mg/5 mL (17 May 2023)
      • Penicillin VK 250 mg, 500 mg tablets (17 May 2023)
    • Polymyxin B sulfate/Trimethoprim sulfate ophthalmic solution (31 Mar 2023)
    • Rifaximin 200 mg tablets (11 Apr 2024)
  • Antifungal drugs: 
    
    • Amphotericin B Lipid Complex (5 Aug 2022)
    • Nystatin oral suspension (21 June 2024)
  • Antimycobacterial drugs: 
    
    • Isoniazid 100 mg, 300 mg tablets (1 Sep 2022)
    • Isoniazid injection 100 mg/mL (24 Jan 2024)
  • Antiparasitic drugs:
    • Nitazoxanide oral susp 100 mg/5 mL (15 Feb 2024)
  • Antiviral drugs: 
    
    • Acyclovir injection (21 Feb 2024)
    • Oseltamivir 30 mg, 45 mg, 75 mg capsules (1 Nov 2022)
    • Oseltamivir powder for oral suspension (1 Nov 2022)
    • Ribavirin for inhalation solution (23 May 2023)
    • Valganciclovir powder for oral solution (7 Feb 2023)
    • Valganciclovir 450 mg tablets (7 Feb 2023)

• For more detailed information including estimated resupply dates, see https://www.ashp.org/Drug-Shortages/